个人简介
吴涛，博士，教授，博士生导师。2008年6月毕业于华中农业大学预防兽医专业，获得农学博士学位，师从著名的猪病学专家陈焕春院士。2008年7月入校工作，2011年获批副教授资格，同年被聘为硕士生导师；2015年10月受国家留学基金委委派赴加拿大农业部农业与农业食品研究中心（AAFC）进行访学交流1年；2017年10月受“中法杰出青年科学家”项目资助赴法国农业科学研究院（INRA）进行访学交流；2018年获批教授资格，2019年被俄罗斯普希诺国家自然科学研究院聘为博士生导师。系中国饲料工业协会生物饲料技术委员会委员、全国饲料工业标准化技术委员会微生物及酶制剂标准化工作组委员、湖北省畜牧兽医学会常务理事、武汉市畜牧兽医学会委员。主要从事动物肠道菌群、功能性益生菌及饲用微生态制剂等相关领域的应用及基础研究，具有畜牧学与兽医学的学科背景。主持或参入国家自然科学基金项目，国家“十三五”、“十四五”重点研发计划项目，湖北省重点研发计划项目等省部级课题20余项，承担横向项目10余项；获湖北省科技进步一等奖1项、技术发明一等奖1项、技术成果推广应用二等奖1项；获的授权发明专利20余项，转化专利10余项；发表学术论文60余篇，其中SCI论文30余篇，参编学术著作1部，参入译著1部。
科研项目
1、十四五国家重点研发计划项目子课题：玉米塘渣蛋白质高质化技术研究与应用。（2024YFD1300403-2）
2、湖北省农业科技攻关项目：新型饲用微生物、酶的产品创制（HBNYHXGG2024-10）
3、湖北省教育厅创新团队：基于仔猪肠道脂质代谢的营养调控技术的建立及应用研究（T2023010）
4、十四五国家重点研发计划项目子课题：抗仔猪腹泻的益生菌筛选与机制研究及产品研发。（2022YFD1300404-2）
5、武汉市基础研究类纵向课题：母猪产道菌群对仔猪PEDV感染的影响及机制研究。（2022020801010392）
6、湖北省科技创新专项项目：基于猪肠道健康营养调控技术创新与应用。（2021BBA083）
7、湖北省重大科技专项：基于多组学技术的仔猪肠道功能营养调控剂筛选与产品开发。（2019ABA083）
8、湖北省重大科技专项：基于猪鸡肠道功能靶标的微生态制剂创制与应用。（2018ABA110）
9、十三五国家重点研发计划项目子课题:消化道微生物调控畜禽营养过程及机体健康的机制。（2017YFD0500505）
10、湖北省研究开发计划（国际合作项目）：基于宏基因组学技术的仔猪益生菌和益生元的研发。（2017AHB062）
11、2013国家自然科学基金项目：猪链球菌2型分子伴侣trigger factor调控机制研究。（31302089）
12、2012年湖北省自然科学基金项目：Trigger factor对猪链球菌2型毒力及耐受性调控的分子机制研究。（2012FFBO4804）
13、2012年湖北省教育厅科技计划项目：表达猪表皮生长因子的重组嗜酸乳杆菌的构建及应用研究。（D20121804）
14、2011年国家科技支撑计划项目：饲用乳酸菌标准化检测技术研究。（2011BAD26B02-4）
15、2010年湖北省研究与开发计划项目：新型饲用益生菌、粘附素及酶制剂的研究与开发。（2010BB023）
发明专利
1、猪肠道损伤的无损检测方法ZL 2021 1 0676411.2
2、鞣花酸在制备治疗或预防猪病毒性腹泻药物或饲料添加剂中的应用，ZL2021 11360738.5
3、一种凝结芽孢杆菌及其发酵方法、凝结芽孢杆菌制剂的制备方法以及猪饲料、ZL2017111181860
4、新生仔猪肠道正常健康功能菌群早期建立方法、ZL2017114980545
5、肌酸在制备治疗或预防猪病原性腹泻药物或饲料添加剂中的应用、ZL202411805499.3
6、根皮素在制备治疗或预防猪囊膜病毒感染药物或饲料添加剂中的应用、ZL202411819866.5
7、金合欢醇在制备治疗或预防鸡坏死性肠炎药物或饲料添加剂中的应用、ZL202510033958.9
8、一种复合植物多酚螯合物及其使用方法、ZL202210347360.3
9、一种猪流行性腹泻病毒的3C样蛋白酶抑制剂及其筛选方法、以及其应用、ZL202110855357.8
10、一种抗猪囊膜病毒感染的多糖组合物、制备方法及其应用、ZL202411805588.8
11、葛根素在制备防治猪病毒感染的药物中的用途、防治猪病毒感染的药物及猪饲料添加剂、ZL201711498123.2
12、一种猪干扰素诱生剂的筛选方法、ZL201711498133.6
13、一种抗猪流行性腹泻病毒感染的组合物及其应用、ZL201910755961.6
14、用于饲料中添加的保加利亚乳杆菌的快速定性、定量检测试剂盒及检测方法和应用，ZL201510854943.5
15、用于饲料中添加的干酪乳杆菌的快速定性、定量检测试剂盒及检测方法和应用，ZL201510856158.3
16、用于饲料中添加的粪肠球菌的快速定性、定量检测试剂盒及检测方法和应用，ZL201510860782.0
17、用于饲料中添加的屎肠球菌的快速定性、定量检测试剂盒及检测方法和应用，专利号：ZL201510854914.9
18、用于饲料中添加的嗜酸乳杆菌的快速定性、定量检测试剂盒及检测方法和应用，ZL201510860823.6
19、用于饲料中添加的双歧杆菌的快速定性、定量检测试剂盒及检测方法和应用，ZL201510856101.3
20、用于饲料中添加的植物乳杆菌的快速定性、定量检测试剂盒及检测方法和应用，ZL201510854975.5
21、一种N-乙酰-L-半胱氨酸在制备治疗或预防猪病毒感染药物中的应用、ZL201410726587.4
22、一种表达猪表皮生长因子的重组嗜酸乳杆菌的构建方法及用途、ZL201310038835.1
23、一种表达猪胰高血糖素样肽-2的重组嗜酸乳杆菌的构建方法及用途、ZL201310037473.4
代表性论文
[1] Tianjing Liao†, Yi Zhang†, Huanhuan Ma†, Zhanchang Wang, Ao Zhou, Yu Zhang, Zhengfan Zhang, Shuangshuang Guo, Yongqing Hou, Zhonghua Li* and Tao Wu*. Isolation and pathogenicity of a variant porcine epidemic diarrhea virus field strain with high adaptability to Vero cell. Front. Vet. Sci. 12:1654230. doi: 10.3389/fvets.2025.1654230.
[2] Zhang Q†, Wang MJ†, Li ZH, Zhao D, Hou YQ, Wu T*. Fucoidan alleviates porcine epidemic diarrhea virus-induced intestinal damage in piglets by enhancing antioxidant capacity and modulating arginine metabolism. Animals (Basel). 2025,15(7):1001.
[3] Zhang XH†, Sun LY†, Wu MJ†, Yu CM, Zhao D, Wang L, Zhang ZF, Yi D, Hou YQ, Wu T*. Effect of supplementation with Lactobacillus rhamnosus GG powder on intestinal and liver damage in broiler chickens challenged by lipopolysaccharide. Front Microbiol. 2024, 15:1466274.
[4] Li HX†, Wu MJ†, Li ZH, Zhang Q, Zhang XH, Zhang YY, Zhao D, Wang L, Hou YQ,Wu T*. Effect of supplementation with yeast polysaccharides on intestinal function in piglets infected with porcine epidemic diarrhea virus. Front Microbiol. 2024, 15:1378070.
[5] Yu CM†, Wu MJ†, Sun LY, Li HX, Xu ZY, Zhang Q, Yi D, Wang L, Zhao D, Hou YQ, Wu T*. Effect of supplementation with black soldier fly extract on intestinal function in piglets infected with porcine epidemic diarrhea virus. Animals. 2024, 14(10):1512.
[6] Xu ZY†, Zhang Q†, Wu MJ, Zhang YY, Li ZH, Li HX, Yu CM, Zhang XH, Zhao D, Wang L, Hou YQ, Wu T*. Lactobacillus rhamnosus GG powder supplementation alleviates intestinal injury in piglets challenged by porcine epidemic diarrhea virus. Front Cell Infect Microbiol. 2024, 14:1371916.
[7] Li Z, Zhu L, Wang L, Huang Y, Zhang Y, Zhao D, Wang L, Yi D, Hou Y and Wu T* (2024). Identification of two flavonoids antiviral inhibitors targeting 3C-like protease of porcine epidemic diarrhea virus.Front. Microbiol. 15:1357470.doi: 10.3389/fmicb.2024.1357470
[8] Zhang Q, Zhang L, Du LX, Zhang YY, Yi D, Zhao D, Ding BY, Hou YQ, Wu T*. Dietary supplementation of natural tannin relieved intestinal injury and oxidative stress in piglets challenged with enterotoxigenic Escherichia coli. Czech J Anim Sci. 2023,68(7):296-305
[9] Cheng B, Huang M, Zhou T, Deng Q, Teketay Wassie, Wu T*, Wu X*. Garlic essential oil supplementation modulates colonic microbiota compositions and regulates immune response in weaned piglets. Heliyon. 2023, 9(8):e18729.
[10] Wu T†, Zhang Q†, Xu HW, Li P, Zhao D, Wang L, Yi D, Hou YQ*. Protective effects of α-terpineol and Bacillus coagulans on intestinal function in weaned piglets infected with a recombinant Escherichia coli expressing heat-stable enterotoxin STa. Front Vet Sci. 2023, 10:1118957.
[11] Zhang Q, Zhang LJ, Lyu Y, Shi YT, Zhu LY, Zhang M, Zhao YY, Zhao D, Wang L, Yi D, Hou YQ, Wu T*. Dietary supplementation of Lactobacillus zeae regulated the gut microbiome in piglets infected with enterotoxigenic Escherichia coli. Czech Journal of Animal Science. 2022, 67: 27-38.
[12] Zhang Q†, Li P†, Li HB†, Yi D, Guo SS, Wang L, Zhao D, Wang C, Wu T*, Hou YQ* (2022) Multifaceted effects and mechanisms of N-acetylcysteine on intestinal injury in a porcine epidemic diarrhea virus-infected porcine model. Mol Nutr Food Res. 2022, 66(24):e2200369 .
[13] Yanyan Zhang†,Tao Wu†, Zhenqiang Chen†, Yuxuan Meng, Zhekun Zhu, Qian Wang, Junjie Tian, Dan Yi, Lei Wang, Di Zhao and Yongqing Hou*. Dietary Supplementation with Enterococcus faecium R1 Attenuates Intestinal and Liver Injury in Piglets Challenged by Lipopolysaccharide. Animals, 2021, 11(5): 1424.
[14] Wu T†, Shi YT†, Zhang YY, Zhang M, Zhang LJ, Ma ZP, Zhao D, Wang L, Yu H, Hou YQ*, Gong J*. Lactobacillus rhamnosus LB1 alleviates enterotoxigenic escherichia coli-induced adverse effects in piglets by improving host immune response and anti-oxidation stress and restoring intestinal integrity. Front Cell Infect Microbiol. 2021, 2011:724401.
[15] Zhang Q†, Wu T†, Li SY†, Meng YX, Tan ZH, Wu MJ, Yi D, Wang L, Zhao D, Hou YQ*. Protective effect of zinc oxide and its association with neutrophil degranulation in piglets infected with porcine epidemic diarrhea virus. Oxid Med Cell Longev. 2021:3055810.
[16] Mengjun Wu, Dan Yi, Qian Zhang,Tao Wu, Kui Yu, Meng Peng, Lei Wang, Di Zhao, Yongqing Hou & Guoyao Wu. Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus. Scientific reports 11.1 (2021): 1-14.
[17] Wu T, Li K, Lyu Y, Yi D, Zhao D, Wang L, Ding BY, Hou YQ*, Wu G. Trilactic glyceride regulates lipid metabolism and improves gut function in piglets. Frontiers in Bioscience-Landmark. 2020, 25: 1324-1336.
[18] Huiyun Wang, Chengcheng Li, Meng Peng, Lei Wang, Di Zhao,Tao Wu, Dan Yi, Yongqing Hou & Guoyao. N-Acetylcysteine improves intestinal function and attenuates intestinal autophagy in piglets challenged withβ-conglycinin[J]. Scientific reports, 2021, 11(1): 1-14.
[19] Mengjun Wu†, Qian Zhang†, Dan Yi†,Tao Wu, Hongbo Chen, Shuangshuang Guo, Siyuan Li, Changzheng Ji, Lei Wang, Di Zhao, Yongqing Hou*and Guoyao Wu. Quantitative Proteomic Analysis Reveals Antiviral and Anti-inflammatory Effects of Puerarin in Piglets Infected With Porcine Epidemic Diarrhea Virus. Frontiers in immunology, 2020, 11: 169.
[20] Tao Wu†, Yang Lyu†, Xueni Li, Mengjun Wu, Kui Yu, Siyuan Li, Changzheng Ji, Qian Zhang, Yanyan Zhang, Di Zhao, Dan Yi, and Yongqing Hou*. Impact of N-Acetylcysteine on the Gut Microbiota in the Piglets Infected With Porcine Epidemic Diarrhea Virus. Frontiers in Veterinary Science, 2020, 7.
[21] Junmei Zhang, Di Zhao, Dan Yi, Mengjun Wu, Hongbo Chen,Tao Wu, Jia Zhou, Peng Li, Yongqing Hou & Guoyao Wu. Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus. Scientific reports, 2019, 9(1): 1-12.
[22] Chengcheng Li, Meng Peng, Man Liao, Shuangshuang Guo, Yongqing Hou, Binying Ding,Tao Wu, and Dan Yi*. Effects of N-acetylcysteine on the energy status and antioxidant capacity in heart and liver of cold-stressed broilers.Asian-Australasian journal of animal sciences, 2020, 33(9): 1444.
[23] Wu Tao, Li Kang, Lyu Yang, Yi Dan, Zhao Di, Wang Lei, Ding Bingying, Hou Yongqing, Wu Guoyao. Trilactic glyceride regulates lipid metabolism and improves gut function in piglets. Frontiers in bioscience (Landmark edition), 2020, 25: 1324-1336.
[24] Tao Wu, Kang Li, Dan Yi, Lei Wang, Di Zhao, Yang Lv, Lin Zhang, Hongbo Chen, Binying Ding, Yongqing Hou, and Guoyao Wu. Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets. International journal of molecular sciences19.10 (2018):3277. /
[25] Tao Wu, Yang Lv, Xueni Li, Lin Zhang, Yutao Shi, Lixiao Du, Dan Yi, Hongbo Chen, Shuangshuang Guo, Lei Wang, Di Zhao, Binying Ding, Yongqing Hou, Joshua Gong. Beneficial Impact and Molecular Mechanism of Bacillus coagulans on Piglets’Intestine. International journal of molecular sciences 19.7 (2018): 2084.
[26] Tao Wu, Yang Lv, Xueni Li, Di Zhao, Dan Yi, Lei Wang, Peng Li, Hongbo Chen, Yongqing Hou, Joshua Gong, Guoyao Wu. (2018). Establishment of a recombinant Escherichia coli-induced piglet diarrhea model. Frontiers in bioscience (Landmark edition), 23, 1517-1534.
[27] Yang Lv, Ping Kang, Lin Zhang, Xueni Li, Lei Wang, Di Zhao, Dan Yi, Binying Ding, Hongbo Chen, Yongqing Hou,Tao Wu* (2018). Generation of epidermal growth factor and green fluorescent protein coexpressing Lactobacillus acidophilus and its effect on intestinal histology improvement in mature LPS-challenged mice. The Thai Journal of Veterinary Medicine, 48(2), 147-156.
[28] Yang Lv, Xueni Li, Lin Zhang, Yutao Shi, Linxiao DU, Binying DING, Yongqing HOU, Joshua GONG,Tao Wu*. (2018). Injury and mechanism of recombinant E. coli expressing STa on piglets colon. Journal of Veterinary Medical Science, 80(2), 205-212.
[29] Yi D,Li B,Hou YQ*,Wang L,Zhao D,Chen H,Wu T,Zhou Y,Ding B,Wu GY. Dietary supplementation with an amino acid blend enhances intestinal function in piglets.Amino Acids,2018, 50: 1089-1100.
[30] Yi D,Liu W,Hou YQ*,Wang L,Zhao D,Wu T,Ding B,Wu GY. Establishment of a porcine model of indomethacin-induced intestinal injury.Frontiers in Bioscience(Landmark),2018, 23: 2166-2176.
[31] Yi D, Fang QH, Hou YQ*, Wang L, Xu HW,Wu T, Gong J, Wu GY. Dietary supplementation with oleum cinnamomi improves intestinal functions in piglets.International Journal of Molecular Sciences, 2018, 19:1284-1297.
[32] Wang L, Zhou J, Hou YQ*, Yi D, Ding BY, Xie JQ, Zhang Y, Chen HB,Wu T, Zhao D, Hu CA, Wu GY. N-Acetylcysteine supplementation alleviates intestinal injury in piglets infected by porcine epidemic diarrhea virus.Amino Acids, 2017, 49: 1931-1943.
[33] Yi D, Hou YQ*, Xiao H, Wang L, Zhang Y, Chen HB,Wu T, Ding BY, Hu CA, Wu GY. N-Acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways.Amino Acids, 2017, 49: 1915-1929.
[34] Yi D, Hou YQ*, Wang L, Zhao D, Ding BY,Wu T, Chen HB, Liu YL, Kang P, Wu GY. Gene expression profiles in the intestine of lipopolysaccharide-challenged piglets.Frontiers in Bioscience (Landmark), 2016, 21: 487-501.
Di Zhao†,Wu T†, Dan Yi, Lei Wang, Peng Li, Junmei Zhang , Yongqing Hou,*and Guoyao Wu (2017). Dietary Supplementation with Lactobacillus casei Alleviates Lipopolysaccharide-Induced Liver Injury in a Porcine Model. International journal of molecular sciences, 18(12), 2535.
主要奖励及个人荣誉
1、湖北省科技进步一等奖：猪禽肠道健康营养调控关键技术及应用（2024年）
2、湖北省技术发明奖一等奖：基于猪肠道功能靶标的饲料添加剂研制与应用（2017年）
3、湖北省成果推广奖二等奖：畜禽肠道功能调控关键技术推广应用（2020年）
4、武汉轻工大学优秀硕士生导师（2023年）
5、武汉轻工大学优秀基层党务工作者（2023年）
6、武汉轻工大学师德先进个人（2022年）
7、武汉轻工大学优秀基层党务工作者（2021年）
