办公地址：武汉轻工大学食品科技楼619
联系电话： 15337162761
电子邮箱：yandz6808@163.com，dazhongyan@whpu.edu.cn
闫达中，理学博士，教授，博士生导师。俄罗斯普希诺国家自然科学院Pushchino State Institute of Natural Sciences (Russian Federation)外聘博士生导师，美国康奈尔大学访问学者。现在武汉轻工大学生命科学与技术学院从事科研和教学工作。主要从事微生物代谢的分子机制，酶工程和生物转化方面的研究。主持国家自然科学基金面上项目2项，参与国家自然科学基金面上项目3项，主持湖北省科技厅面上项目和教育厅基金项目各1项，主持企业横向合作项目共8项。发表文章50多篇，其中SCI收录36篇。申请专利6项，参编教材5部。
教育经历：
2003/09-2006/7，中国科学院武汉病毒研究所，微生物学，博士；
2000/09-2003/07，湖北大学，生命科学院，生物化学与分子生物学，硕士。
工作经历：
2006/07-至今：武汉轻工大学，生物与制药工程学院，教授。
2015/08-2016/08： 康奈尔大学（Cornell University）访问学者。
主要研究方向：
（1）微生物功能基因组学研究，微生物降解环境污染物的分子机理研究；
（2）酶工程，饲料、食品和工业用酶的研发；
（3）生物转化，生物转化生产高附加值药物。
主要承担的科研项目：
1. 国家自然科学基金面上项目，菌株Raoultella sp. YL01降解棉酚的代谢途径及分子机制研究（32070098），2021/01-2024/12，主持。
2. 国家自然科学基金面上项目，假单胞菌NyZ12降解环己胺的分子机理研究（31270112），2013/01-2016/12，主持。
3. 国家自然科学基金青年项目，印染厂活性污泥宏基因文库中脱色酶的克隆及其脱色机理的研究（31800111）， 2019/01-2021/12, 25万，参与。
4. 国家自然科学基金面上项目，弱活性小分子分泌蛋白BC1G_01444在灰葡萄孢与植物互作过程中的功能机理研究（31972215），2020/01-2023/12, 参与。
5. 国家自然科学基金面上项目，农杆菌CHJ606降解塑料抗氧化剂2,4-二叔丁基苯酚的途径及分子机制研究(32470124)， 2025/01-2028/12，参与。
6. 湖北省重点研发计划项目，绿色生物高分子絮凝剂制备关键技术研究与示范（2022BCA075），2022/7-2024/12，参与。
7. 菊粉益生元健康食品全产业链关键技术开发及应用， 2018020402011230，2018/02-2021/02，参与。
8. 湖北省自然科学基金项目，2008CDB067，氯氰菊酯的微生物降解途径和机理研究，主持。
9. 湖北省教育厅科技计划项目，Q200718003，溶栓活性乳酸菌的构建，2007/01-2009/12，主持。
10. 湖北省自然科学基金项目, 2014CFC1133,宏基因组中脱色酶基因资源的挖掘与分子改造, 2014/01-2017/12 ，参与。
11. 湖北省教育厅科技计划项目，D20121808，高胆固醇负荷通过UPR途径诱导肝细胞炎性损伤机制研究，2012/01-2014/12, 参与。
12．湖北省自然科学基金项目，2011CDB227，条件致病菌烟曲霉内醚糖激酶基因的功能研究，2011/12-2014/12，参与。
代表性论文与著作
通讯作者*或 第一作者：
1. Liang T, Chen J, Li J, Dong ML, Han Z, Shan FJ, Gao XW, Yan DZ*. Characterization of a novel alginate lyase Alg0392 with organic solvent-tolerance from Alteromonas sp. A1-6. Appl Microbiol Biotechnol. 2025, 109(1): 122.
2． Wu J, Han Z, Li P, Li J, Chen Y, Ning S, Chao HJ, Gao XW, Yan D*. Crystal structure of cyclohexylamine oxidase from Acinetobacter sp. YT-02 reveals key residues for catalytic activity and substrate specificity. Enzyme Microb Technol. 2025，190:110700.
3. Chen J, Zhao S, Gan Y, Wu J, Dai J, Chao HJ, Yan D*. Dichlorodiphenyltrichloroethane inhibits soil ammonia oxidation by altering ammonia-oxidizing archaeal and bacterial communities. Environ Pollut. 2023 333:122063.
4. Chen S, Zhang W, Zhang H, Cui Y, Wang F, Wu J, Chao H, Yan D*. The Complete Genome Sequence of a Gossypol-Degrading Bacterial Strain, Raoultella sp. YL01. Curr Microbiol. 2023, 80(5):163.
5. Ning S, Chao HJ, Li S, Zhou R, Zou L, Zhang X, Liu J, Yan D*, Duan M*. The auto-inhibition mechanism of transcription factor Ets-1 induced by phosphorylation on the intrinsically disordered region. Comput Struct Biotechnol J. 2022, 20: 1132-1141.
6. Li X, Yang HQ, Zhou ML, Zhan YY, Liu J, Yan DZ*, Cai DB, Chen SW*. A novel strategy of feeding nitrate for cost-effective production of poly-γ-glutamic acid from crude glycerol by Bacillus licheniformis WX-02. Biochem Eng J, 2021,176: 108156
7. Tang K, Cui Y, Xiao J, Ding M, Chao H, Wu J, Han Z, Liu J, Li X, Yan DZ*. Molecular cloning and characterization of a novel xylanase from Microbacterium imperiale YD-01. J Food Biochem. 2021 ,45(12):e13988.
8. Chen YY, Li Y, Chao HJ, Wu J, Zhu WJ, Fang T, Gao XW, Yan DZ *. Molecular cloning and characterisation of a novel xanthine oxidase from Cellulosimicrobium cellulans ATCC21606. Process Biochem. 2020, 91: 65-72
9. Ning SB, Liu J, Liu N*, Yan DZ *. The accuracy of force fields on the simulation of intrinsically disordered proteins: a benchmark test on the human p53 tumor suppressor, Journal of Theo Comput Chem, 2020. 19(4): 2050011
10. Chen S, Feng H, Li X, Chao HJ,Wu J, Liu J, Zhu WJ, Yan DZ*. The complete genome sequence of a bacterial strain with high alkalic xylanase activity isolated from the sludge near a papermill. Curr Microbiol. 2020, 77(12): 3945–3952.
11.Liu J, Han Q, Cheng Q, Chen Y, Wang R, Li X, Liu Y, Yan D*. Efficient expression of human lysozyme through the increased gene dosage and co-expression of transcription factor Hac1p in Pichia pastoris. Curr Microbiol. 2020 . 77(5): 846-854
12. Chao HJ, Chen YY, Wu J, Yan DZ*, Zhou NY. Complete genome sequence of a chlorobenzene degrader, Pandoraea pnomenusa MCB032. Curr Microbiol. 2019, 76(11):1235-1237
13. Zhou H, Han ZG, Fang T, Chen YY, Ning SB, Gan YT, Yan DZ*. Characterization of a new cyclohexylamine oxidase from Acinetobacter sp. YT-02. Front Microbiol. 2018, 9: 2848.
14. Yan DZ, Gan YT, Zhou H, Liu J, Li X. Draft genome sequence of cyclohexylamine-degrading strain Acinetobacter sp. YT-02 isolated. Curr Microbiol. 2018, 75(3):284-287.
15. Yan DZ*, Li X, Li CZ, Mao LQ, Chi XQ, Zhou NY, Liu DY. Genome-wide identification and characterization of genes encoding cyclohexylamine degradation in a novel cyclohexylamine-degrading bacterial strain of Pseudomonas plecoglossicida NyZ12. J Biotechnol, 2017, 251:166-173.
16. Li X, Li CZ, Mao LQ, Yan DZ*, Zhou NY. Complete genome sequence of the cyclohexylamine-degrading Pseudomonas plecoglossicida NyZ12. J Biotechnol. 2015, 199: 29-30.
17. Liu J, Yan DZ*, Zhao SJ. Expression of monellin in a food-grade delivery system in Saccharomyces cerevisiae. J Sci Food Agr, 2015, 95(13): 2646–2651.
18. Yan DZ, Mao LQ, Li CZ, Liu J. Biodegradation of hexachlorobenzene by a constructed microbial consortium. World J Microbiol Biotechnol. 2015, 31(2) : 371-377.
19. Yan DZ, Kang JX, Liu DQ . Genomic analysis of the aromatic catabolic pathways from Silicibacter pomeroyi DSS-3. Ann Microbiol, 2009, 59 (4): 789-800.
20. Yan DZ, Liu H, Zhou NY. Conversion of Sphingobium chlorophenolicum ATCC 39723 to a hexachlorobenzene degrader by metabolic engineering. Appl Environ Microbiol. 2006, 72(3): 2283-2286.
非通讯作者或非第一作者：
1. Liu F, Chen J, Xu Y, Qin F, Yan D, Chao HJ, Dai J, Wu J. Hexachlorobutadiene pollution affected soil ammonia oxidation processes through affecting ammonia oxidizing microorganisms. Ecotoxicol Environ Saf. 2025, 301:118498.
2. Xiong JX, Du LS, Li NN, Wu XT, Xiang Y, Li S, Zou L, Liu D, Huang D, Xie ZF, Wang Y, Li J, Dai J, Yan D, Chao HJ. Pigmentiphaga kullae CHJ604 improved the growth of tobacco by degrading allelochemicals and xenobiotics in continuous cropping obstacles. J Hazard Mater. 2024, 465:133466.
3. Wang Z, Zhou H, Cheng Y, An L, Yan D, Chao H, Wu J. Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability. Biotechnol Lett. 2024, 46(4):627-639.
4. Xiang Y, Xiong JX, Xie ZF, Huang D, Song Q, Wu J, Yan D, Chao HJ. The XylR/NtrC-type regulator CbsR positively regulates upstream pathway of chlorobenzene degradation in Pandoraea pnomenusa. J Appl Microbiol. 2023 ，134(4):lxad064.
5. Yao NH, Du YN, Xiong JX, Xiao Y, He HH, Xie ZF, Huang D, Song Q, Chen J, Yan D, Chao HJ. Microbial detoxification of 3,5-xylenol via a novel process with sequential methyl oxidation by Rhodococcus sp. CHJ602. Environ Res. 2023 220:115258.
6. Yao NH, Liu X, Luo CY, Zou L, Li JH, Chen J, Yan D, Chao HJ. Methylhydroxylase encoded by mchAB gene is involved in methyl oxidation of m-cresol via Comamonas thiooxydans CHJ601. International Biodeterioration & Biodegradation. 2023, 179: 105583.
7. Zou L, Li S, Li N, Ruan SL, Chen J, Wu J, Yan D, Chao HJ. The Protocatechuate 3,4-Dioxygenase Solubility (PCDS) Tag Enhances the Expression and Solubility of Heterogenous Proteins in Escherichia coli. Front Microbiol. 2021, 12:779541.
8. Huang L, Luo D, Gondil VS, Gong Y, Jia M, Yan D, He J, Hu S*, Yang H*, Wei H*. Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo. Appl Microbiol Biotechnol. 2020, 104(4):1609-1619.
9. Tao W, Chen L, Zhao C, Wu J, Yan D, Deng Z, Sun Y. In Vitro Packaging Mediated One-Step Targeted Cloning of Natural Product Pathway. ACS Synth Biol. 2019, 8(9): 1991-1997.
10. Zhu W*, Xu X, Peng F, Yan DZ, Zhang S, Xu R, Wu J, Li X, Wei W, Chen W. The cyclase-associated protein ChCAP is important for regulation of hyphal growth, appressorial development, penetration, pathogenicity, conidiation, intracellular cAMP level, and stress tolerance in Colletotrichum higginsianum. Plant Sci. 2019, 283: 1-10.
11. Zhu W, Dong H, Xu R, You J, Yan DZ, Xiong C, Wu J, Bi K. Botrytis cinerea BcCDI1 protein triggers both plant cell death and immune response. Front Plant Sci. 2023 , 14:1136463.
12. Yao X, Lu B, Lü C, Bai Q, Yan D, Xu H. Taraxerol induces cell apoptosis through A mitochondria-mediated pathway in HeLa cells. Cell J. 2017, 19(3): 512-519
13. Yao X, Lu B, Lü C, Bai Q, Yan D, Wu Y, Hong Z, Xu H. Solanesol induces the expression of heme oxygenase-1 via p38 and Akt and suppresses the production of proinflammatory cytokines in RAW264.7 cells. Food Funct. 2017, 8(1): 132-141.
14. Yao X, Bai Q, Yan D, Li G, Lü C, Xu H. Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70. Toxicol In Vitro. 2015, 29(3): 600-608.
15. Shen Y, Yan DZ, Chi XQ, Yang YY, Leak DJ, Zhou NY. Degradation of cyclohexylamine by a new isolate of Pseudomonas plecoglossicida. World J Microbiol Biotechnol. 2008, 24: 1623-1625.
16. Xu Y, Yan DZ, Zhou NY. Heterologous expression and localization of gentisate transporter Ncg12922 from Corynebacterium glutamicum ATCC 13032. Biochem Biophys Res Commun. 2006, 346(2): 555-561.
专利成果：
1. 闫达中; 耐热碱性木聚糖酶基因xylGT优化序列及其高效表达方法, 2018-02-23, ZL 201410679215.0. 授权号：CN104450758B
2. 闫达中; 可用于临床检测的黄嘌呤氧化酶、其编码基因及其应用, 2020-03-20, ZL201710262579.2 授权号：CN107119059B
3. 闫达中，晁红军，吴菁，李柔柔。产果胶酶芽孢杆菌及其发酵方法、以及胡椒脱皮的方法. 2022-07-22 专利号： ZL202110288142.2 授权号：CN113151055 B
4. 闫达中， 晁红军， 吴菁， 刘军， 李鑫. 木聚糖酶基因xylA1及其应用.
2023-04-25 专利号：ZL 202111409381.5 授权公告号：CN114085823B
5. 闫达中，梁俊龙，吴菁， 晁红军，戴景程，陈静。 一种根癌农杆菌及应用。
20230516 专利号： ZL202210260785.0 授权公告号：CN 114958644B
获奖：
多次校级课堂教学质量奖获得者;
省级生物学实验竞赛生物化学、分子生物学一等奖指导老师.
其他
参编 国家“十三五”规划教材《基础分子生物学》(第2-4版)
